Chilicothe

Marah macrocarpa has the most pubescent shoots, stems, and leaves of all the Marah species native to California - this being consistent with its range having the most xeric climate. Vines appear in late winter in response to increased rainfall, and can climb or scramble to a length of 6 metres (20 ft). The subspecies M. m. major of the Channel Islands (California) is about twice as large in all of its parts. For example, the mainland leaves are 5 to 10 centimeters wide while the insular leaves are 15 to 25 centimeters in width. And the seeds on the mainland are 15 to 20 millimeters long while the insular seeds are 28 to 33 millimeters in length. Vines emerge from a large, hard tuberous root which can reach several meters in length and weigh in excess of 100 kilograms (220 lb). Weights of up to 500 pounds (227 kilograms) have been reported. Vines develop leaves and, particularly, flowers and fruit very quickly, often with the first nodes of the quick-growing vines containing male and female flower heads. Its leaves typically have five lobes with individual plants showing wide variation in leaf size and lobe length.

Flower The flower can vary in color from yellowish green to cream to white. Flowers appear soon after the vine emerges. The flowers are monoecious, that is, individual flowers are either male or female, but both sexes can be found on the same plant. …

Marah macrocarpa is native to Southern California in the United States and Baja California, Mexico. Its range extends from the Transverse Ranges and Channel Islands through the Peninsular Ranges, and the Sonoran Desert. M. macrocarpa is bounded to the north by the Santa Clara River, which also forms the southern boundary for Marah fabacea. It occurs throughout Baja California and its adjacent Pacific islands, including Cedros Island.

It grows by streams, in washes, and on slopes in chaparral and oak woodlands, at elevations up to 900 m (3,000 ft). It will tolerate a variety of soil types and acidities, but it requires seasonally moist soil. Vines can grow in full-sun to partially shaded conditions. It emerges soon after winter rains begin, grows until late spring, and dies back completely in the heat and dryness of summer.

Ethnographic accounts report that the most common use of Marah macrocarpa was for treating hair loss and baldness on the head. It was reported that the Chumash, Kawaiisu, and Cahuilla peoples roasted the seeds and mashed them into an oily black salve that was applied to the head. Pharmacological research suggests that the Cucurbitacins found in Marah are structurally similar to the antiandrogen medication finasteride and may show similar biological activity, providing support to the traditional uses of the plants for treating hair loss. The Kumeyaay, Luiseño, Kawaiisu, and Tongva peoples also used M. macrocarpa for the relief of pain and inflammation. The black salve from the roasted seeds was applied to areas of irritation or sores. The black salve was also used for body painting. All parts of the plants are toxic due to the presence of cucurbitacins and ribosome-inactivating proteins, so it was not traditionally consumed. Other Marah species in different regions were historically consumed in difficult conditions to commit suicide or euthanasia.