Pandoraea

Pandoraea is a genus of Gram-negative, non-spore-forming, motile bacteria with a single polar flagellum, from the family Burkholderiaceae and class Betaproteobacteria.

Pandoraea spp. are increasingly reported as opportunistic pathogens in patients with cystic fibrosis, immunocompromised hosts, and critically ill individuals. These bacteria display intrinsic multidrug resistance, with frequent resistance to β-lactams, aminoglycosides, fluoroquinolones and polymyxins. Imipenem and trimethoprim-sulfamethoxazole are the agents that most often retain activity, although clinical data remain limited and standardized susceptibility breakpoints are lacking.